Jeun, Minhong Park, Sungwook Lee, Hakho Lee, Kwan Hyi 2024-01-20T03:30:55Z 2024-01-20T03:30:55Z 2021-09-03 2016-10 1176-9114 https://pubs.kist.re.kr/handle/201004/123650 Magnetic-based biosensors are attractive for on-site detection of biomarkers due to the low magnetic susceptibility of biological samples. Here, we report a highly sensitive magnetic-based biosensing system that is composed of a miniaturized nuclear magnetic resonance (NMR) device and magnetically engineered nanoferrite particles (NFPs). The sensing performance, also identified as the transverse relaxation (R-2) rate, of the NMR device is directly related to the magnetic properties of the NFPs. Therefore, we developed magnetically engineered NFPs (MnMg-NFP) and used them as NMR agents to exhibit a significantly improved R-2 rate. The magnetization of the MnMg-NFPs was increased by controlling the Mn and Mg cation concentration and distribution during the synthesis process. This modification of the Mn and Mg cation directly contributed to improving the R-2 rate. The miniaturized NMR system, combined with the magnetically engineered MnMg-NFPs, successfully detected a small amount of infectious influenza A H1N1 nucleoprotein with high sensitivity and stability. English DOVE MEDICAL PRESS LTD CARE-ASSOCIATED INFECTIONS NANOPARTICLES RELAXATION DIAGNOSIS SPHERES CANCER CELLS Highly sensitive detection of protein biomarkers via nuclear magnetic resonance biosensor with magnetically engineered nanoferrite particles Article 10.2147/IJN.S118156 1 INTERNATIONAL JOURNAL OF NANOMEDICINE, v.11, pp.5497 - 5503 INTERNATIONAL JOURNAL OF NANOMEDICINE 11 5497 5503 scie scopus 000386231000003 2-s2.0-84994440915 Nanoscience & Nanotechnology Pharmacology & Pharmacy Science & Technology - Other Topics Pharmacology & Pharmacy Article CARE-ASSOCIATED INFECTIONS NANOPARTICLES RELAXATION DIAGNOSIS SPHERES CANCER CELLS biosensor NMR nanoferrite particles transverse relaxation magnetization onsite detection