Shahriari, Yalda Krusienski, Dean Dadi, Yamini Sureka Seo, Misun Shin, Hee-Sup Choi, Jee Hyun 2024-01-20T03:32:12Z 2024-01-20T03:32:12Z 2021-09-05 2016-09 1562-2975 https://pubs.kist.re.kr/handle/201004/123716 Objectives: In patients with schizophrenia, -band (30-70Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether -ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Methods: Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C 1 (PLC-1) null mice during auditory binaural click trains at different rates (20-50Hz), and compared with wild-type littermates. Results: In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the band (20Hz) but not in the band, whereas the phase locking in auditory cortex was reduced in the band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. Conclusions: The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia. English TAYLOR & FRANCIS LTD GAMMA BAND OSCILLATIONS PARVALBUMIN NEURONS PREFRONTAL CORTEX NMDA RECEPTOR MICE RESPONSES BRAIN PHOSPHOLIPASE-C-BETA-1 SYNCHRONIZATION ENDOPHENOTYPES Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model Article 10.3109/15622975.2015.1112036 1 WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.17, no.6, pp.439 - 448 WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 17 6 439 448 scie scopus 000383408000004 2-s2.0-84955142417 Psychiatry Psychiatry Article GAMMA BAND OSCILLATIONS PARVALBUMIN NEURONS PREFRONTAL CORTEX NMDA RECEPTOR MICE RESPONSES BRAIN PHOSPHOLIPASE-C-BETA-1 SYNCHRONIZATION ENDOPHENOTYPES Schizophrenia mouse auditory-steady-state-response EEG oscillations