Kim, Ji-Hoon Han, Gi-Chan Seo, Ji-Yun Park, Inkuk Park, Wookjin Jeong, Hyun-Woo Lee, Su Hyeon Bae, Sung-hwan Seong, Jinwoo Yum, Min-Kyu Hann, Sang-Hyeon Kwon, Young-Guen Seo, Daekwan Choi, Man Ho Kong, Young-Yun 2024-01-20T03:32:32Z 2024-01-20T03:32:32Z 2021-09-05 2016-09 1465-7392 https://pubs.kist.re.kr/handle/201004/123735 Quiescent satellite cells, known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle following injury throughout life. Although they mainly originate from multipotent stem/progenitor cells of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb 1 (Mib1) expression in myofibres at puberty, which activates Notch signalling in cycling juvenile satellite cells and causes them to be converted into adult quiescent satellite cells. Myofibres lacking Mib1 fail to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Our findings reveal that the hypothalamic-pituitary-gonadal axis drives Mibi expression in the myofibre niche. Moreover, the same axis regulates the re-establishment of quiescent satellite cell populations following injury. Our data show that sex hormones establish adult quiescent satellite cell populations by regulating the myofibre niche at puberty and re-establish them during regeneration. English NATURE PUBLISHING GROUP ESTROGEN-RECEPTOR-ALPHA HUMAN SKELETAL-MUSCLE PROGENITOR CELLS SATELLITE CELLS ANDROGEN RECEPTOR MIND BOMB-1 NOTCH ACTIVATION TESTOSTERONE EXPRESSION MOUSE Sex hormones establish a reserve pool of adult muscle stem cells Article 10.1038/ncb3401 1 NATURE CELL BIOLOGY, v.18, no.9, pp.930 - 940 NATURE CELL BIOLOGY 18 9 930 940 scie scopus 000382416800004 2-s2.0-84983483218 Cell Biology Cell Biology Article ESTROGEN-RECEPTOR-ALPHA HUMAN SKELETAL-MUSCLE PROGENITOR CELLS SATELLITE CELLS ANDROGEN RECEPTOR MIND BOMB-1 NOTCH ACTIVATION TESTOSTERONE EXPRESSION MOUSE sex steroid muscle stem cell Mind Bomb 1 HPG axis Notch signal