Ji, Jae-hoon Shin, Kyeong-sik Kang, Shinill Lee, Soo Hyun Kang, Ji Yoon Kim, Sinyoung Jun, Seong Chan 2024-01-20T03:33:30Z 2024-01-20T03:33:30Z 2021-09-05 2016-08-15 0956-5663 https://pubs.kist.re.kr/handle/201004/123787 We present a new diagnostic technique of fundamental monomeric biomaterials that do not rely on any enzyme or chemical reaction. Instead, it only uses radio frequency (RF) signal analysis. The detection and classification of basic biomaterials, such as glucose and albumin, were demonstrated. The device was designed to generate a strong resonance response with glucose solution and fabricated by simple photolithography with PDMS (Polydimethylsiloxane) well. It even was used to detect the level of glucose in mixtures of glucose and albumin and in human serum, and it operated properly and identified the glucose concentration precisely. It has a detection limit about 100 mu M (1.8 mg/dl), and a sensitivity about 58 MHz per 1 mM of glucose and exhibited a good linearity in human blood glucose level. In addition, the intrinsic electrical properties of biomaterials can be investigated by a de-embedding technique and an equivalent circuit analysis. The capacitance of glucose containing samples exhibited bell-shaped Gaussian dispersion spectra around 2.4 GHz. The Albumin solution did not represent a clear dispersion spectra compared to glucose, and the magnitude of resistance and inductance of albumin was higher than that of other samples. Other parameters also represented distinguishable patterns to classify those biomaterials. It leads us to expect future usage of our technique as a pattern-recognizing biosensor. (C) 2016 Published by Elsevier B.V. English ELSEVIER ADVANCED TECHNOLOGY BOVINE SERUM-ALBUMIN DIELECTRIC-RELAXATION ELECTRICAL-PROPERTIES AQUEOUS-SOLUTIONS CARBON NANOTUBES GLUCOSE SENSORS GLASSY STATES LIQUID TEMPERATURE MODULATION Fundamental monomeric biomaterial diagnostics by radio frequency signal analysis Article 10.1016/j.bios.2016.03.016 1 BIOSENSORS & BIOELECTRONICS, v.82, pp.255 - 261 BIOSENSORS & BIOELECTRONICS 82 255 261 scie scopus 000376545400037 2-s2.0-84963984676 Biophysics Biotechnology & Applied Microbiology Chemistry, Analytical Electrochemistry Nanoscience & Nanotechnology Biophysics Biotechnology & Applied Microbiology Chemistry Electrochemistry Science & Technology - Other Topics Article BOVINE SERUM-ALBUMIN DIELECTRIC-RELAXATION ELECTRICAL-PROPERTIES AQUEOUS-SOLUTIONS CARBON NANOTUBES GLUCOSE SENSORS GLASSY STATES LIQUID TEMPERATURE MODULATION Biosensor Biomaterial diagnostics Bio-detection Label-free Dielectric relaxation Radio-frequency