Xie, Yu Guan, Ying Kim, Soo-Hyun King, Martin W. 2024-01-20T03:34:11Z 2024-01-20T03:34:11Z 2021-09-05 2016-08 1751-6161 https://pubs.kist.re.kr/handle/201004/123825 Cardiovascular disease (CVD) accounts for a significant mortality rate worldwide. Autologous vessels, such as the saphenous vein and the internal mammary artery, are currently the gold standard materials for by-pass surgery. However, they may not always be available due to aging, previous harvesting or the pre-existing arterial disease. Synthetic commercial ePTFE and polyester (PET) are not suitable for small diameter vascular grafts (<6 mm), mainly due to their poor circumferential compliance, rapid thrombus formation and low endothelialization. In order to reduce thrombogenicity and improve cell proliferation, we developed a collagen/elastin knitted/electrospun bilayer graft made of biodegradable and biocompatible poly(lactic acid) (PLA) and poly(lactide-co-caprolactone) (PLCL) polymers to mimic the multilayer structure of native arteries. We also designed the prostheses to provide some of the required mechanical properties. While the bilayer structure had excellent circumferential tensile strength, bursting strength and suture retention resistance, the radial compliance did not show any observable improvement. (C) 2016 Elsevier Ltd. All rights reserved. English ELSEVIER SCIENCE BV CORONARY-ARTERY IN-VITRO GRAFTS SCAFFOLDS COLLAGEN ELASTIN POLYCAPROLACTONE ARCHITECTURE FABRICATION VIVO The mechanical performance of weft-knitted/electrospun bilayer small diameter vascular prostheses Article 10.1016/j.jmbbm.2016.04.011 1 JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v.61, pp.410 - 418 JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 61 410 418 scie scopus 000380080400038 2-s2.0-84963943956 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article CORONARY-ARTERY IN-VITRO GRAFTS SCAFFOLDS COLLAGEN ELASTIN POLYCAPROLACTONE ARCHITECTURE FABRICATION VIVO Knitting Electrospinning Vascular prosthesis Biodegradable polymer Collagen impregnation Elastin impregnation Mechanical performance