Jeon, Hyeonjeong Kim, Jihoon Lee, Yeong Mi Kim, Jinhwan Choi, Hyung Woo Lee, Junseok Park, Hyeongmok Kang, Youngnam Kim, In-San Lee, Byung-Heon Hoffman, Allan S. Kim, Won Jong 2024-01-20T04:02:21Z 2024-01-20T04:02:21Z 2021-09-04 2016-06-10 0168-3659 https://pubs.kist.re.kr/handle/201004/123970 This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, beta-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between beta-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems. (C) 2016 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV IRON-OXIDE NANOPARTICLES BETA-CYCLODEXTRIN IN-VIVO CANCER THERAPEUTICS ANTICANCER DRUG THERAPY PACLITAXEL RELEASE CARRIER TUMORS Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system Article 10.1016/j.jconrel.2016.01.006 1 JOURNAL OF CONTROLLED RELEASE, v.231, pp.68 - 76 JOURNAL OF CONTROLLED RELEASE 231 68 76 scie scopus 000376444600008 2-s2.0-84954306031 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article; Proceedings Paper IRON-OXIDE NANOPARTICLES BETA-CYCLODEXTRIN IN-VIVO CANCER THERAPEUTICS ANTICANCER DRUG THERAPY PACLITAXEL RELEASE CARRIER TUMORS Multivalent host-guest chemistry Paclitaxel Cyclodextrin SPION Magnetic-guided drug delivery