Lee, Seung Hwan Ha, Sang Keun Choi, Inwook Choi, Nakwon Park, Tai Hyun Sung, Jong Hwan 2024-01-20T04:02:51Z 2024-01-20T04:02:51Z 2021-09-05 2016-06 1860-6768 https://pubs.kist.re.kr/handle/201004/123998 After drug administration, the drugs are absorbed, distributed, metabolized, and excreted (ADME). Because ADME processes affect drug efficacy, various in vitro models have been developed based on the ADME processes. Although these models have been widely accepted as a tool for predicting the effects of drugs, the differences between in vivo and in vitro systems result in high attrition rates of drugs during the development process and remain a major limitation. Recent advances in microtechnology enable more accurate mimicking of the in vivo environment, where cellular behavior and physiological responses to drugs are more realistic; this has led to the development of novel in vitro systems, known as "organ-on-a-chip" systems. The development of organ-on-a-chip systems has progressed to include the reproduction of multiple organ interactions, which is an important step towards "body-on-a-chip" systems that will ultimately predict whole-body responses to drugs. In this review, we summarize the application of microtechnology for the development of in vitro systems that accurately mimic in vivo environments and reconstruct multiple organ models. English WILEY-V C H VERLAG GMBH CELL-CULTURE ANALOG CUT LIVER SLICES ON-A-CHIP IN-VITRO INTESTINAL SCAFFOLDS CACO-2 MONOLAYERS BIOREACTOR METABOLISM TOXICITY PERMEABILITY Microtechnology-based organ systems and whole-body models for drug screening Article 10.1002/biot.201500551 1 BIOTECHNOLOGY JOURNAL, v.11, no.6, pp.746 - 756 BIOTECHNOLOGY JOURNAL 11 6 746 756 scie scopus 000379785700004 2-s2.0-84973402398 Biochemical Research Methods Biotechnology & Applied Microbiology Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Article CELL-CULTURE ANALOG CUT LIVER SLICES ON-A-CHIP IN-VITRO INTESTINAL SCAFFOLDS CACO-2 MONOLAYERS BIOREACTOR METABOLISM TOXICITY PERMEABILITY In vitro systems Microfluidics Microtechnology Multiple organ interaction Organ-on-a-chip