Park, Jin-Kyung Kim, Ran Hee Prabhakaran, Prem Kim, Sehoon Lee, Kwang-Sup 2024-01-20T04:04:29Z 2024-01-20T04:04:29Z 2021-09-05 2016-05-01 2159-3930 https://pubs.kist.re.kr/handle/201004/124083 We report the synthesis and biological studies of a fluorescence dye with an oligoethylene glycol substituted (OEG) perylene centered dye N, N'-(2,6-diisopropylphenyl)-1-[oligo(ethylene glycol) methyl ether]1,6,7,12- trichloroperylene-3,4: 9,10-tetracarboxdiimide (PDI-OEG). The activity of the dye is juxtaposed with a precursor molecule without the OEG substitution. The OEG substitution contributes to the increased biocompatibility of PDI-OEG. Cell viability studies lead to the survival of more than 80% of the PDI-OEG cultured cells endorsing its biocompatibility. Fluorescence imaging studies were carried out using multiple cell lines. Ex-vivo studies involving nude mice were used to establish liver and lung specific organ targeting of PDI-OEG. This fluorophore is an excellent example of a stable and biocompatible red emitting small molecule for bioimaging. (C) 2016 Optical Society of America English OPTICAL SOC AMER Highly biocompatible amphiphilic perylenediimide derivative for bioimaging Article 10.1364/OME.6.001420 1 OPTICAL MATERIALS EXPRESS, v.6, no.5, pp.1420 - 1428 OPTICAL MATERIALS EXPRESS 6 5 1420 1428 scie scopus 000376242000001 2-s2.0-84975764659 Materials Science, Multidisciplinary Optics Materials Science Optics Article