Storace, Douglas Rad, Masoud Sepehri Kang, BokEum Cohen, Lawrence B. Hughes, Thom Baker, Bradley J. 2024-01-20T04:30:24Z 2024-01-20T04:30:24Z 2021-09-05 2016-05 0166-2236 https://pubs.kist.re.kr/handle/201004/124107 Genetically encoded optical sensors of cell activity are powerful tools that can be targeted to specific cell types. This is especially important in neuroscience because individual brain regions can include a multitude of different cell types. Optical imaging allows for simultaneous recording from numerous neurons or brain regions. Optical signals of membrane potential are useful because membrane potential changes are a direct sign of both synaptic and action potentials. Here we describe recent improvements in the in vitro and in vivo signal size and kinetics of genetically encoded voltage indicators (GEVIs) and discuss their relationship to alternative sensors of neural activity. English ELSEVIER SCIENCE LONDON NEOCORTICAL PYRAMIDAL NEURONS FLUORESCENT VOLTAGE SENSOR DENDRITIC CALCIUM DYNAMICS PROTEIN VOLTAGE IN-VIVO ELECTRICAL-ACTIVITY OPTICAL ELECTROPHYSIOLOGY SENSING DOMAIN INDICATORS SPIKES Toward Better Genetically Encoded Sensors of Membrane Potential Article 10.1016/j.tins.2016.02.005 1 TRENDS IN NEUROSCIENCES, v.39, no.5, pp.277 - 289 TRENDS IN NEUROSCIENCES 39 5 277 289 scie scopus 000375740300001 2-s2.0-84964388596 Neurosciences Neurosciences & Neurology Review NEOCORTICAL PYRAMIDAL NEURONS FLUORESCENT VOLTAGE SENSOR DENDRITIC CALCIUM DYNAMICS PROTEIN VOLTAGE IN-VIVO ELECTRICAL-ACTIVITY OPTICAL ELECTROPHYSIOLOGY SENSING DOMAIN INDICATORS SPIKES Ehud Isacoff Genetically encoded calcium indicators (GECIs) Genetically encoded voltage indicators (GEVIs) Thomas Knopfel