Kim, Kyungim Oh, Keun Sang Park, Dal Yong Lee, Jae Young Lee, Beom Suk Kim, In San Kim, Kwangmeyung Kwon, Ick Chan Kim, SangYoon Yuk, Soon Hong 2024-01-20T04:31:24Z 2024-01-20T04:31:24Z 2021-09-04 2016-04-28 0168-3659 https://pubs.kist.re.kr/handle/201004/124159 A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer. (C) 2016 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV INVASIVE BLADDER-CANCER OXIDE) TRIBLOCK COPOLYMERS COATED GOLD NANOPARTICLES RADIATION-THERAPY VESICLE FUSION BREAST-CANCER LUNG-CANCER RADIOTHERAPY DELIVERY MICELLES Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting Article 10.1016/j.jconrel.2016.03.009 1 JOURNAL OF CONTROLLED RELEASE, v.228, pp.141 - 149 JOURNAL OF CONTROLLED RELEASE 228 141 149 scie scopus 000373429600015 2-s2.0-84960931563 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article INVASIVE BLADDER-CANCER OXIDE) TRIBLOCK COPOLYMERS COATED GOLD NANOPARTICLES RADIATION-THERAPY VESICLE FUSION BREAST-CANCER LUNG-CANCER RADIOTHERAPY DELIVERY MICELLES Combination therapy Radiotherapy Core/shell nanoparticles Gold nanoparticles Doxorubicin