Kim, J.H. Kim, S.M. Cha, K.H. Mok, I.-K. Koo, S.Y. Pan, C.-H. Lee, J.K. 2024-01-20T04:33:24Z 2024-01-20T04:33:24Z 2021-09-02 2016-04 2468-0834 https://pubs.kist.re.kr/handle/201004/124269 Phaeodactylum tricornutum (PT) is a classical model diatom widely used in ecology, physiology, biochemistry, and molecular biology studies. We evaluated the anti-obesity effects of PT powder based on a number of metabolic parameters in a model of diet-induced obesity. We fed C57BL/6 mice a high-fat diet supplemented with PT powder (15 or 30？% w/v) for 12？weeks, and determined energy intake, weight loss, and lipid profiles each week. PT powder significantly reduced body weight gain, and epididymal and perirenal adipose tissue weight via activation of AMPK and HMGCR pathways. Moreover, we found that fucoxanthin, the putative anti-obesity compound in PT, was effectively micellized and transferred to the soluble fraction at the ileum in an in vitro simulated digestion system. Our results indicate that PT powder has an anti-obesity effect and suggest that it is a candidate substance for the development of anti-obesity foods, supplements, and even drugs. ？ 2016, The Korean Society for Applied Biological Chemistry. English Springer Netherlands Evaluation of the anti-obesity effect of the microalga Phaeodactylum tricornutum Article 10.1007/s13765-016-0151-1 1 Applied Biological Chemistry, v.59, no.2, pp.283 - 290 Applied Biological Chemistry 59 2 283 290 scie scopus kci ART002104104 000377416800016 2-s2.0-84977558850 Food Science & Technology Food Science & Technology Article ACTIVATED PROTEIN-KINASE HIGH-FAT DIET LIPID-METABOLISM BETA-CAROTENE DEGRADATION KINETICS LYCOPENE DEGRADATION MODEL SYSTEM WEIGHT-GAIN FUCOXANTHIN MICE Fucoxanthin Obesity Phaeodactylum tricornutum