You, Dong Gil Deepagan, V. G. Um, Wooram Jeon, Sangmin Son, Sejin Chang, Hyeyoun Yoon, Hwa In Cho, Yong Woo Swierczewska, Maggie Lee, Seulki Pomper, Martin G. Kwon, Ick Chan Kim, Kwangmeyung Park, Jae Hyung 2024-01-20T04:33:41Z 2024-01-20T04:33:41Z 2021-09-05 2016-03-21 2045-2322 https://pubs.kist.re.kr/handle/201004/124279 The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo. English NATURE RESEARCH INTENSITY FOCUSED ULTRASOUND PHOTODYNAMIC THERAPY CHEMOTHERAPY CELLS HIFU COMBINATION CAVITATION TOXICITY DELIVERY ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer Article 10.1038/srep23200 1 SCIENTIFIC REPORTS, v.6 SCIENTIFIC REPORTS 6 scie scopus 000372439600001 2-s2.0-84961825380 Multidisciplinary Sciences Science & Technology - Other Topics Article INTENSITY FOCUSED ULTRASOUND PHOTODYNAMIC THERAPY CHEMOTHERAPY CELLS HIFU COMBINATION CAVITATION TOXICITY DELIVERY photodynamic therapy reactive oxygen species Ultrasound