Lee, Jangwook Jeong, Eun Ju Lee, Yeon Kyung Kim, Kwangmeyung Kwon, Ick Chan Lee, Kuen Yong 2024-01-20T04:34:04Z 2024-01-20T04:34:04Z 2021-09-04 2016-03-02 1613-6810 https://pubs.kist.re.kr/handle/201004/124300 Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible poly(D,L-lactide-co-glycolide) (PLG) nanoparticles containing an imaging probe and therapeutic gene are prepared, followed by modification with rabies virus glycoprotein (RVG) peptide for neuroblastoma-targeting delivery. RVG peptide is a well-known neuronal targeting ligand and is chemically conjugated to PLG nanoparticles without changing their size or shape. RVG-modified nanoparticles are effective in specifically targeting neuroblastoma both in vitro and in vivo. RVG-modified nanoparticles loaded with a fluorescent probe are useful to detect the tumor site in a neuroblastoma-bearing mouse model, and those encapsulating a therapeutic gene cocktail (siMyc, siBcl-2, and siVEGF) significantly suppressed tumor growth in the mouse model. This approach to designing and tailoring of polymeric nanoparticles for targeted delivery may be useful in the development of multimodality systems for theranostic approaches. English WILEY-V C H VERLAG GMBH NICOTINIC ACETYLCHOLINE-RECEPTORS DRUG-DELIVERY MULTIFUNCTIONAL NANOPARTICLES PLGA NANOPARTICLES CANCER-THERAPY CELLS GLYCOPROTEIN PEPTIDE NANOTECHNOLOGY PROLIFERATION Optical Imaging and Gene Therapy with Neuroblastoma-Targeting Polymeric Nanoparticles for Potential Theranostic Applications Article 10.1002/smll.201501913 1 SMALL, v.12, no.9, pp.1201 - 1211 SMALL 12 9 1201 1211 scie scopus 000372008600012 2-s2.0-84960115074 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article NICOTINIC ACETYLCHOLINE-RECEPTORS DRUG-DELIVERY MULTIFUNCTIONAL NANOPARTICLES PLGA NANOPARTICLES CANCER-THERAPY CELLS GLYCOPROTEIN PEPTIDE NANOTECHNOLOGY PROLIFERATION neuroblastoma rabies virus glycoprotein peptides targeted delivery theranostics