Kim, Young-Min Kim, Chang-Ho Song, Soo-Chang 2024-01-20T04:34:32Z 2024-01-20T04:34:32Z 2021-09-05 2016-03 2161-1653 https://pubs.kist.re.kr/handle/201004/124324 We developed an injectable chemical drug/gene dual delivery platform system for long-term combination therapy. Ternary nanosized thermosensitive polymer/chemical drug/gene-(PCG) complexes showing sol gel transition were prepared by simple mixing of three components via hydrophobic and ionic interaction. The PCG complex hydrogel showed sustained release of chemical drug and genes for 40 days without denaturalization of genes in vitro. Dual delivery-mediated anticancer effects of PCG complexes were shown in vitro and in an in vivo xenograft model for up to 1 month. Therefore, this dual delivery platform is expected to be a new effective system for treatment of diseases via long-term chemical drug/gene combination therapy. English AMER CHEMICAL SOC CANCER SYSTEM CHEMOTHERAPY THERAPY SIRNA Injectable Ternary Nanocomplex Hydrogel for Long-Term Chemical Drug/Gene Dual Delivery Article 10.1021/acsmacrolett.6b00008 1 ACS MACRO LETTERS, v.5, no.3, pp.297 - 300 ACS MACRO LETTERS 5 3 297 300 scie scopus 000372395900008 2-s2.0-84961855326 Polymer Science Polymer Science Article CANCER SYSTEM CHEMOTHERAPY THERAPY SIRNA