Abdelazem, Ahmed Z. Al-Sanea, Mohammad M. Park, Hyun-Mee Lee, So Ha 2024-01-20T05:01:02Z 2024-01-20T05:01:02Z 2021-09-05 2016-02-15 0960-894X https://pubs.kist.re.kr/handle/201004/124380 A new series of diarylamides, having a pyrimidinyl pyridine scaffold, was designed and synthesized. The target compounds were synthesized in three steps. A selected group from the target compounds was tested over a panel of 60 cancer cell lines at a single dose concentration of 10 mu M, and the most active compound, 5j, was further tested in a five-dose testing mode to determine its IC50 value over the 60 cell lines. In single-dose testing mode, compound 5j showed the highest growth inhibition against the NCI-60 cancer cell lines, while other tested compounds showed a weak to moderate inhibitory activity against a range of different cancer cell lines. In five-dose testing mode, compound 5j showed strong inhibitory activity in micro molar range against many cancer cell lines. Its major activity was against melanoma cancer cell lines. Therefore, compound 5j is a promising hit compound targeting this severe form of cancer. (C) 2016 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. PRELIMINARY CYTOTOXICITY EVALUATION DERIVATIVES DIARYLUREAS Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and evaluation of their anti-proliferative effect on cancer cell lines Article 10.1016/j.bmcl.2016.01.014 1 Bioorganic & Medicinal Chemistry Letters, v.26, no.4, pp.1301 - 1304 Bioorganic & Medicinal Chemistry Letters 26 4 1301 1304 scie scopus 000369377700041 2-s2.0-84958101799 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article PRELIMINARY CYTOTOXICITY EVALUATION DERIVATIVES DIARYLUREAS Synthesis Anti-proliferative effect Pyrimidinyl pyridine Diarylamide Melanoma