Lee, Jangwook Min, Hyun-Su You, Dong Gil Kim, Kwangmeyung Kwon, Ick Chan Rhim, Taiyoun Lee, Kuen Yong 2024-01-20T05:01:11Z 2024-01-20T05:01:11Z 2021-09-04 2016-02-10 0168-3659 https://pubs.kist.re.kr/handle/201004/124388 The development of safe and efficient diagnostic/therapeutic agents for treating cancer in clinics remains challenging due to the potential toxicity of conventional agents. Although the annual incidence of neuroblastoma is not that high, the disease mainly occurs in children, a population vulnerable to toxic contrast agents and therapeutics. We demonstrate here that cancer-targeting, gas-generating polymeric nanoparticles are useful as a theranostic tool for ultrasound (US) imaging and treating neuroblastoma. We encapsulated calcium carbonate using poly(D,L-lactide-co-glycolide) and created gas-generating polymer nanoparticles (GNPs). These nanoparticles release carbon dioxide bubbles under acidic conditions and enhance US signals. When GNPs are modified using rabies virus glycoprotein (RVG) peptide, a targeting moiety to neuroblastoma, RVG-GNPs effectively accumulate at the tumor site and substantially enhance US signals in a tumor-bearing mousemodel. Intravenous administration of RVG-GNPs also reduces tumor growth in the mouse model without the use of conventional therapeutic agents. This approach to developing theranostic agents with disease-targeting ability may provide useful strategy for the detection and treatment of cancers, allowing safe and efficient clinical applications with fewer side effects than may occur with conventional agents. (C) 2015 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV DRUG-DELIVERY CONTRAST AGENTS GENE DELIVERY NECROSIS THERAPY MICROBUBBLES AUTOPHAGY ABLATION Theranostic gas-generating nanoparticles for targeted ultrasound imaging and treatment of neuroblastoma Article 10.1016/j.jconrel.2015.12.051 1 JOURNAL OF CONTROLLED RELEASE, v.223, pp.197 - 206 JOURNAL OF CONTROLLED RELEASE 223 197 206 scie scopus 000368788900019 2-s2.0-84953270962 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article DRUG-DELIVERY CONTRAST AGENTS GENE DELIVERY NECROSIS THERAPY MICROBUBBLES AUTOPHAGY ABLATION Gas-generating nanoparticle Neuroblastoma Theranostic system Rabies virus glycoprotein