Some, Surajit Sohn, Ji Soo Kim, Junmoo Lee, Su-Hyun Lee, Su Chan Lee, Jungpyo Shackery, Iman Kim, Sang Kyum Kim, So Hyun Choi, Nakwon Cho, Il-Joo Jung, Hyo-Il Kang, Shinill Jun, Seong Chan 2024-01-20T05:01:23Z 2024-01-20T05:01:23Z 2021-09-05 2016-02-04 2045-2322 https://pubs.kist.re.kr/handle/201004/124399 Graphene-composites, capable of inhibiting bacterial growth which is also bio-compatible with human cells have been highly sought after. Here we report for the first time the preparation of new graphene-iodine nano-composites via electrostatic interactions between positively charged graphene derivatives and triiodide anions. The resulting composites were characterized by X-ray photoemission spectroscopy, UV-spectroscopy, Raman spectroscopy and Scanning electron microscopy. The antibacterial potential of these graphene-iodine composites against Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirobilis, Staphylococcus aureus, and E. coli was investigated. In addition, the cytotoxicity of the nanocomposite with human cells [human white blood cells (WBC), HeLa, MDA-MB-231, Fibroblast (primary human keratinocyte) and Keratinocyte (immortalized fibroblast)], was assessed. DGO (Double-oxidizes graphene oxide) was prepared by the additional oxidation of GO (graphene oxide). This generates more oxygen containing functional groups that can readily trap more H+, thus generating a positively charged surface area under highly acidic conditions. This step allowed bonding with a greater number of anionic triiodides and generated the most potent antibacterial agent among graphene-iodine and as-made povidone-iodine (PVP-I) composites also exhibited nontoxic to human cells culture. Thus, these nano-composites can be used to inhibit the growth of various bacterial species. Importantly, they are also very low-cytotoxic to human cells culture. English NATURE PUBLISHING GROUP SILVER NANOPARTICLES OXIDE AGENT NANOMATERIALS COMPOSITES Graphene-Iodine Nanocomposites: Highly Potent Bacterial Inhibitors that are Bio-compatible with Human Cells Article 10.1038/srep20015 1 SCIENTIFIC REPORTS, v.6 SCIENTIFIC REPORTS 6 scie scopus 000369273100001 2-s2.0-84957588240 Multidisciplinary Sciences Science & Technology - Other Topics Article SILVER NANOPARTICLES OXIDE AGENT NANOMATERIALS COMPOSITES