Lee, Dahae Ko, Hyeonseok Kim, Young-Joo Kim, Su-Nam Choi, Kyung-Chul Yamabe, Noriko Kim, Ki Hyun Kang, Ki Sung Kim, Hyun Young Shibamoto, Takayuki 2024-01-20T05:01:26Z 2024-01-20T05:01:26Z 2021-09-05 2016-02-03 0021-8561 https://pubs.kist.re.kr/handle/201004/124401 The effects of a red raspberry component, sanguiin H-6 (SH-6), on the induction of apoptosis and the related signaling pathways in A2780 human ovarian carcinoma cells were investigated. SH-6 caused an antiproliferative effect and a severe morphological change resembling that of apoptotic cell death but no effect on the cancer cell cycle arrest: In addition, SH-6 induced an early apoptotic effect and activation of caspases as well as the deavage of PARP, which is a hallmark of apoptosis. The early apoptotic percentages of A2780 cells exposed to 20 and 40 mu M SH-6 were 35.39 and 41.76, respectively. Also, SH-6 caused the activation of mitogen-activated protein, kinases (MAPKs), especially p38, and the increase of truncated p15/BID. These results in the present study suggest that the apoptosis of A2780 human ovarian carcinoma cells by SH-6 is mediated by the MAPK p38 and a caspase-8-dependent BID cleavage pathway. English AMER CHEMICAL SOC CANCER RESISTANCE APOPTOSIS PHENOLICS Inhibition of A2780 Human Ovarian Carcinoma Cell Proliferation by a Rubus Component, Sanguiin H-6 Article 10.1021/acs.jafc.5b05461 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.4, pp.801 - 805 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64 4 801 805 scie scopus 000369557200009 2-s2.0-84956962687 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article CANCER RESISTANCE APOPTOSIS PHENOLICS apoptosis A2780 ovarian carcinoma cells caspase MAPK p38 polyphenols raspberry sanguiin H-6 truncated BID