Kim, Kyoung-Ran Bang, Duhee Ahn, Dae-Ro 2024-01-20T05:02:53Z 2024-01-20T05:02:53Z 2021-09-03 2016-02 2047-4830 https://pubs.kist.re.kr/handle/201004/124478 Photodynamic therapy (PDT) is a cytotoxic treatment using singlet oxygen produced by photosensitizers. Approved porphyrinoid PDT still suffers from a lack of robust production methods and low water solubility. Methylene blue (MB) is a good candidate for the PDT drug, because the dye is an effective photosensitizer, can be easily synthesized, and is already being used in other clinical fields. However, its poor cell/tissue penetration and low stability against the reducible biological conditions should be addressed by using a proper delivery vehicle. Here, we employed a DNA tetrahedron, a self-assembled nanostructure as the carrier for intracellular delivery of MB by taking advantage of the DNA binding property of the photosensitizer and demonstrated photo-induced cytotoxicity by the MB delivered by the DNA nanocarrier. We also evaluated the PDT potency of the MB-loaded DNA nanoconstruct in vivo tumor model to suppress tumor growth. English ROYAL SOC CHEMISTRY METHYLENE-BLUE DELIVERY Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy Article 10.1039/c5bm00467e 1 BIOMATERIALS SCIENCE, v.4, no.4, pp.605 - 609 BIOMATERIALS SCIENCE 4 4 605 609 scie scopus 000372997600005 2-s2.0-84962076681 Materials Science, Biomaterials Materials Science Article METHYLENE-BLUE DELIVERY DNA tetrahedron cancer photodynamic therapy drug delivery methylene blue