Yang, Sung Jae Jo, Hyoung Kim, Kyung-A Ahn, Hong Ryul Kang, Suk Woo Jung, Sang Hoon 2024-01-20T05:03:43Z 2024-01-20T05:03:43Z 2021-09-03 2016-01-01 1096-620X https://pubs.kist.re.kr/handle/201004/124522 The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100mg/kg EEDK group, and 200mg/kg EEDK group was 43.3%+/- 5.5%, 337.7%+/- 2.5%, and 27.2%+/- 4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats. English MARY ANN LIEBERT, INC MATRIX METALLOPROTEINASE-2 INFLAMMATION EXPRESSION MODEL PERSIMMON TISSUE PEEL Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization Article 10.1089/jmf.2014.3404 1 JOURNAL OF MEDICINAL FOOD, v.19, no.1, pp.106 - 109 JOURNAL OF MEDICINAL FOOD 19 1 106 109 scie scopus kci ART002076630 000367824700013 2-s2.0-84954174374 Chemistry, Medicinal Food Science & Technology Nutrition & Dietetics Pharmacology & Pharmacy Food Science & Technology Nutrition & Dietetics Article MATRIX METALLOPROTEINASE-2 INFLAMMATION EXPRESSION MODEL PERSIMMON TISSUE PEEL alkali burn angiogenic factors corneal neovascularization Diospyros kaki eye diseases