Lee, Won Seok Park, Min Kim, Myung Hun Park, Chun Gwon Huh, Beom Kang Seok, Hyun Kwang Choy, Young Bin 2024-01-20T05:30:16Z 2024-01-20T05:30:16Z 2021-09-03 2016-01 0885-3282 https://pubs.kist.re.kr/handle/201004/124586 In this study, we proposed a potential method for the preparation of a magnesium-based medical device for local drug delivery and controlled corrosion. A magnesium surface was modified with 3-aminopropyltrimethoxy silane, and the resulting surface was then coated with drug-loaded nanoparticles made of poly (lactic-co-glycolic acid) via electrophoretic deposition. The drug-loaded nanoparticles (i.e., Tr_NP) exhibited a size of 250 +/- 67nm and a negative zeta potential of -20.9 +/- 2.75mV. The drug was released from the nanoparticles in a sustained manner for 21 days, and this did not change after their coating on the silane-modified magnesium. The silane-modified surface suppressed magnesium corrosion. When immersed in phosphate buffered saline at pH 7.4, the average rate of hydrogen gas generation was 0.41-0.45ml/cm(2)/day, compared to 0.58-0.6ml/cm(2)/day from a bare magnesium surface. This corrosion profile was not significantly changed after nanoparticle coating under the conditions employed in this work. The invitro cell test revealed that the drug released from the coating was effective during the whole release period of 21 days, and both the silane-modified surface and carrier nanoparticles herein were not cytotoxic. English SAGE PUBLICATIONS LTD BIODEGRADATION BEHAVIOR PLGA NANOPARTICLES IN-VITRO TRANILAST ADHESION ALLOYS STENTS FILMS Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion Article 10.1177/0885328215582110 1 JOURNAL OF BIOMATERIALS APPLICATIONS, v.30, no.6, pp.651 - 661 JOURNAL OF BIOMATERIALS APPLICATIONS 30 6 651 661 scie scopus 000367743400001 2-s2.0-84954305166 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article BIODEGRADATION BEHAVIOR PLGA NANOPARTICLES IN-VITRO TRANILAST ADHESION ALLOYS STENTS FILMS Coating corrosion drug delivery electrophoretic deposition magnesium nanoparticles silane