Cho, Chang Hun Kim, Jiae Ahn, Jee-Yin Hahn, Hoh-Gyu Cho, Sung-Woo 2024-01-20T05:31:09Z 2024-01-20T05:31:09Z 2021-09-03 2015-12-15 0165-5728 https://pubs.kist.re.kr/handle/201004/124628 We report that N-adamanty1-4-methylthiazol-2-amine (KHG26693), a novel thiazole derivative, can prevent lipopolysaccharide (LPS)-induced brain inflammation in mice. In this LPS-induced model of brain inflammation, administration of KHG26693 effectively prevented increases in the levels of IL-1 beta, TNF-alpha, prostaglandin E2, malondialdehyde, and nitric oxide, and mitigated reductions in the levels of superoxide dismutase in the hippocampus. KHG26693 also prevented reductions in the levels of hippocampal brain-derived neurotrophic factors. Furthermore, pretreatment with KHG26693 prior to LPS treatment dramatically attenuated the elevation of inducible nitric oxide synthase and cyclooxygenase-2 protein levels. Moreover, pretreatment with KHG26693 significantly suppressed LPS-induced phosphorylation of NF-kappa B and I kappa B alpha through the inactivation of IKK beta. Additionally, KHG26693 caused the downregulation of LPS-induced cystathionine-b-synthase gene expression in the brain. Although the clinical relevance of our findings remains to be determined, our data suggest that KHG26693 might prevent neuronal cell injury via the reduction of inflammation and oxidative stress in the brain. (C) 2015 Elsevier B.V. All rights reserved. English ELSEVIER TNF-ALPHA 2-CYCLOPROPYLIMINO-3-METHYL-1,3-THIAZOLINE HYDROCHLORIDE INDUCED NEUROINFLAMMATION MICROGLIAL ACTIVATION NITRIC-OXIDE DISEASE MECHANISMS EXPRESSION SYNTHASE DAMAGE N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-kappa B signaling in mice Article 10.1016/j.jneuroim.2015.10.016 1 JOURNAL OF NEUROIMMUNOLOGY, v.289, pp.98 - 104 JOURNAL OF NEUROIMMUNOLOGY 289 98 104 scie scopus 000366784500014 2-s2.0-84947913274 Immunology Neurosciences Immunology Neurosciences & Neurology Article TNF-ALPHA 2-CYCLOPROPYLIMINO-3-METHYL-1,3-THIAZOLINE HYDROCHLORIDE INDUCED NEUROINFLAMMATION MICROGLIAL ACTIVATION NITRIC-OXIDE DISEASE MECHANISMS EXPRESSION SYNTHASE DAMAGE Neuroinflammation Thiazole derivative NF-kappa B INOS COX-2