Park, Jimin Du, Ping Jeon, Jin-Kyung Jang, Gun Hyuk Hwang, Mintai Peter Han, Hyung-Seop Park, Kwideok Lee, Kwan Hyi Lee, Jee-Wook Jeon, Hojeong Kim, Yu-Chan Park, Jong Woong Seok, Hyun-Kwang Ok, Myoung-Ryul 2024-01-20T05:31:24Z 2024-01-20T05:31:24Z 2021-09-03 2015-12 1433-7851 https://pubs.kist.re.kr/handle/201004/124641 Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H2O2 without any external light or voltage. The corrosion of Mg transfers electrons to Au-decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H2O2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H2O2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated. English John Wiley & Sons Ltd. Magnesium Corrosion Triggered Spontaneous Generation of H2O2 on Oxidized Titanium for Promoting Angiogenesis Article 10.1002/anie.201507352 1 Angewandte Chemie International Edition, v.54, no.49, pp.14753 - 14757 Angewandte Chemie International Edition 54 49 14753 14757 N scie scopus 000367723400024 2-s2.0-84983212580 Chemistry, Multidisciplinary Chemistry Article HYDROGEN-PEROXIDE OXYGEN REDUCTION OXIDATION CHEMISTRY BIOLOGY angiogenesis catalysis corrosion magnesium oxygen reduction reaction