Nam, Jin H. Park, Eun S. Won, So-Yoon Lee, Yu A. Kim, Kyoung I. Jeong, Jae Y. Baek, Jeong Y. Cho, Eun J. Jin, Minyoung Chung, Young C. Lee, Byoung D. Kim, Sung Hyun Kim, Eung-Gook Byun, Kyunghee Lee, Bonghee Woo, Dong Ho Lee, C. Justin Kim, Sang R. Bok, Eugene Kim, Yoon-Seong Ahn, Tae-Beom Ko, Hyuk Wan Brahmachari, Saurav Pletinkova, Olga Troconso, Juan C. Dawson, Valina L. Dawson, Ted M. Jin, Byung K. 2024-01-20T05:31:27Z 2024-01-20T05:31:27Z 2021-09-03 2015-12-01 0006-8950 https://pubs.kist.re.kr/handle/201004/124644 Currently there is no neuroprotective or neurorestorative therapy for Parkinson's disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neurons and leads to behavioural recovery through CNTF receptor alpha (CNTFR alpha) on nigral dopamine neurons in both the MPP+-lesioned or adeno-associated virus alpha-synuclein rat models of Parkinson's disease. Western blot and immunohistochemical analysis of human post-mortem substantia nigra from Parkinson's disease suggests that this endogenous neuroprotective system (TRPV1 and CNTF on astrocytes, and CNTFR alpha on dopamine neurons) might have relevance to human Parkinson's disease. Our results suggest that activation of astrocytic TRPV1 activates endogenous neuroprotective machinery in vivo and that it is a novel therapeutic target for the treatment of Parkinson's disease. English OXFORD UNIV PRESS CILIARY NEUROTROPHIC FACTOR ALPHA-SYNUCLEIN REACTIVE ASTROCYTES GLIAL-CELLS RAT EXPRESSION MODEL OVEREXPRESSION RECEPTORS DEGENERATION TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF Article 10.1093/brain/awv297 1 BRAIN, v.138, pp.3610 - 3622 BRAIN 138 3610 3622 scie scopus 000366384600022 2-s2.0-84951197871 Clinical Neurology Neurosciences Neurosciences & Neurology Article CILIARY NEUROTROPHIC FACTOR ALPHA-SYNUCLEIN REACTIVE ASTROCYTES GLIAL-CELLS RAT EXPRESSION MODEL OVEREXPRESSION RECEPTORS DEGENERATION Parkinson&apos s disease TRPV1 astrocyte ciliary neurotrophic factor (CNTF) dopamine neurons