Yi, YoonYoung Park, JiSoo Lim, Jaeho Lee, C. Justin Lee, Sang-Hoon 2024-01-20T05:32:10Z 2024-01-20T05:32:10Z 2021-09-03 2015-12 0167-7799 https://pubs.kist.re.kr/handle/201004/124684 Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models. English ELSEVIER SCIENCE LONDON BLOOD-BRAIN-BARRIER IN-VITRO MODEL MICROFLUIDIC CULTURE PLATFORM ON-A-CHIP REGENERATIVE MEDICINE QUANTITATIVE-ANALYSIS ALZHEIMERS-DISEASE NEURONAL NETWORKS CELL-INTERACTIONS AXONAL INJURY Central Nervous System and its Disease Models on a Chip Article 10.1016/j.tibtech.2015.09.007 1 TRENDS IN BIOTECHNOLOGY, v.33, no.12, pp.762 - 776 TRENDS IN BIOTECHNOLOGY 33 12 762 776 scie scopus 000366768400006 2-s2.0-84947909246 Biotechnology & Applied Microbiology Biotechnology & Applied Microbiology Review BLOOD-BRAIN-BARRIER IN-VITRO MODEL MICROFLUIDIC CULTURE PLATFORM ON-A-CHIP REGENERATIVE MEDICINE QUANTITATIVE-ANALYSIS ALZHEIMERS-DISEASE NEURONAL NETWORKS CELL-INTERACTIONS AXONAL INJURY Brain CNS Microfluidics Neural disease Organ-on-a-chip