Cha, Jin Wook Il Lee, Seung Kim, Min Cheol Thida, Mya Lee, Jae Wook Park, Jin-Soo Kwon, Hak Cheol 2024-01-20T05:33:21Z 2024-01-20T05:33:21Z 2021-09-03 2015-11-15 0960-894X https://pubs.kist.re.kr/handle/201004/124748 New phenazine derivatives with a methylamine linker, Pontemazines A (1) and B (2), were isolated from the culture broth of Streptomyces sp. UT1123. The structures of compounds 1 and 2 were determined by NMR spectroscopy and high-resolution mass spectrometry. These compounds consist of a 9-mehoxyphenazine connected to a benzamide functional group by a unique methylamine linker instead of the more common methyl ether. Pontemazines A and B possess a neuronal cell protective effect on glutamate-induced mouse hippocampal HT-22 cell damage. (C) 2015 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. OXIDATIVE STRESS BIOCONTROL BACTERIA Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp UT1123 and their protective effect to HT-22 neuronal cells Article 10.1016/j.bmcl.2015.10.019 1 Bioorganic & Medicinal Chemistry Letters, v.25, no.22, pp.5083 - 5086 Bioorganic & Medicinal Chemistry Letters 25 22 5083 5086 scie scopus 000364535000013 2-s2.0-84945904589 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article OXIDATIVE STRESS BIOCONTROL BACTERIA Pontemazines Streptomyces Neuroprotection Phenazine Methylamine linkage