Park, Mijeong Kim, Chong-Hyun Jo, Seon mi Kim, Eun Joo Rhim, Hyewhon Lee, C. Justin Kim, Jeansok J. Cho, Jeiwon 2024-01-20T06:00:49Z 2024-01-20T06:00:49Z 2021-09-03 2015-11 2045-2322 https://pubs.kist.re.kr/handle/201004/124860 Chronic uncontrollable stress has been shown to produce various physiological alterations and impair mnemonic functions in the rodent hippocampus. Impacts on neuronal activities, however, have not been well investigated. The present study examined dorsal CA1 place cells to elucidate the computational changes associated with chronic stress effects on cognitive behaviors. After administering chronic restraint stress (CRS; 6 hours/day for >= 21 consecutive days) to adult male mice, several hippocampal characteristics were examined; i.e., spatial learning, in vitro synaptic plasticity, in vivo place cell recording, and western blot analysis to determine protein levels related to learning and memory. Behaviorally, CRS significantly impeded spatial learning but enhanced non-spatial cue learning on the Morris water maze. Physiologically, CRS reduced long-term potentiation (LTP) of Schaffer collateral/commisural-CA1 pathway, phospho-alpha CaMKII (alpha Ca2+/calmodulin-dependent protein kinase II) level in the hippocampus, and stability of spatial representation and the mean firing rates (FRs) of place cells. Moreover, the local cue-dependency of place fields was increased, and the intra-burst interval (IntraBI) between consecutive spikes within a burst was prolonged following CRS. These results extend the previous findings of stress impairing LTP and spatial learning to CRS modifying physical properties of spiking in place cells that contribute to changes in navigation and synaptic plasticity. English NATURE PUBLISHING GROUP Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice Article 10.1038/srep16235 1 SCIENTIFIC REPORTS, v.5 SCIENTIFIC REPORTS 5 N scie scopus 000364295000005 2-s2.0-84946782438 Multidisciplinary Sciences Science & Technology - Other Topics Article LONG-TERM POTENTIATION MULTIPLE MEMORY-SYSTEMS HIPPOCAMPAL-NEURONS DECLARATIVE MEMORY CA1 REGION RAT PLASTICITY LTP INFORMATION STIMULATION