Olsen, Michelle L. Khakh, Baljit S. Skatchkov, Serguei N. Zhou, Min Lee, C. Justin Rouach, Nathalie 2024-01-20T06:01:27Z 2024-01-20T06:01:27Z 2021-09-05 2015-10-14 0270-6474 https://pubs.kist.re.kr/handle/201004/124891 Initial biophysical studies on glial cells nearly 50 years ago identified these cells as being electrically silent. These first studies also demonstrated a large K+ conductance, which led to the notion that glia may regulate extracellular K+ levels homeostatically. This view has now gained critical support from the study of multiple disease models discussed herein. Dysfunction of a major astrocyte K+ channel, Kir4.1, appears as an early pathological event underlying neuronal phenotypes in several neurodevelopmental and neurodegenerative diseases. An expanding list of other astrocyte ion channels, including the calcium-activated ion channel BEST-1, hemichannels, and two-pore domain K+ channels, all contribute to astrocyte biology and CNS function and underpin new forms of crosstalk between neurons and glia. Once considered merely the glue that holds the brain together, it is now increasingly recognized that astrocytes contribute in several fundamental ways to neuronal function. Emerging new insights and future perspectives of this active research area are highlighted within. English SOC NEUROSCIENCE RECTIFYING K+ CHANNEL AMYOTROPHIC-LATERAL-SCLEROSIS GLUTAMATE UPTAKE POTASSIUM CHANNELS TONIC INHIBITION NERVOUS-SYSTEM SPINAL-CORD HIPPOCAMPAL ASTROCYTES SENSORINEURAL DEAFNESS SYNAPTIC-TRANSMISSION New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling Article 10.1523/JNEUROSCI.2603-15.2015 1 JOURNAL OF NEUROSCIENCE, v.35, no.41, pp.13827 - 13835 JOURNAL OF NEUROSCIENCE 35 41 13827 13835 scie scopus 000366051800002 2-s2.0-84944552997 Neurosciences Neurosciences & Neurology Article RECTIFYING K+ CHANNEL AMYOTROPHIC-LATERAL-SCLEROSIS GLUTAMATE UPTAKE POTASSIUM CHANNELS TONIC INHIBITION NERVOUS-SYSTEM SPINAL-CORD HIPPOCAMPAL ASTROCYTES SENSORINEURAL DEAFNESS SYNAPTIC-TRANSMISSION