Kim, Jong Hwan Jang, Mihue Kim, Young-Je Ahn, Hyung Jun 2024-01-20T06:01:33Z 2024-01-20T06:01:33Z 2021-09-05 2015-10-08 0022-2623 https://pubs.kist.re.kr/handle/201004/124896 It is challenging to design rolling circle amplification (RCA) for tumor-selective delivery of drugs. Here, we devise a doxorubicin nanocarrier composed of RCA products, cholesterol-DNA, and folate-DNA conjugates. RCA products, designed to contain tandem repeats of short hairpin DNA, employ the repeated sequences complementary to both DNA conjugates, and thus RCA products/cholesterol-DNA/folate-DNA complexes, generated via sequential base pairing processes, acquire the amphiphilic properties that facilitate self-assembly into the highly condensed nanoparticles (RCA nanoparticles). Doxorubicin-loaded RCA nanopartides, especially with high cargo capacity, release drugs to the environment with the aid of acidity and show selective cytotoxicity to cancer cells. Particularly, the condensed structures enable RCA nanoparticles to be resistant to nucleases in the blood. These results show that RCA nanopartides have great potential as a doxorubicin carrier for targeted cancer therapy, and furthermore, our strategy provides an alternative tool to exploit RCA techniques on drug delivery systems. English AMER CHEMICAL SOC DNA ORIGAMI TARGETED TRANSPORT DELIVERY-SYSTEMS CANCER-CELLS NANOPARTICLES DOXORUBICIN RESISTANCE MICROSPONGES STRATEGIES THERAPY Design and Application of Rolling Circle Amplification for a Tumor-Specific Drug Carrier Article 10.1021/acs.jmedchem.5b01126 1 JOURNAL OF MEDICINAL CHEMISTRY, v.58, no.19, pp.7863 - 7873 JOURNAL OF MEDICINAL CHEMISTRY 58 19 7863 7873 scie scopus 000362701600019 2-s2.0-84943803027 Chemistry, Medicinal Pharmacology & Pharmacy Article DNA ORIGAMI TARGETED TRANSPORT DELIVERY-SYSTEMS CANCER-CELLS NANOPARTICLES DOXORUBICIN RESISTANCE MICROSPONGES STRATEGIES THERAPY DNA nanoparticle anticancer drug drug delivery cancer therapy doxorubicin