Park, Jun Yeon Lee, Dahae Jang, Hyuk-Jai Jang, Dae Sik Kwon, Hak Cheol Kim, Ki Hyun Kim, Su-Nam Hwang, Gwi Seo Kang, Ki Sung Eom, Dae-Woon 2024-01-20T06:02:35Z 2024-01-20T06:02:35Z 2021-09-05 2015-10 1741-427X https://pubs.kist.re.kr/handle/201004/124950 The present study investigated the renoprotective effect of an Artemisia asiatica extract and eupatilin in kidney epithelial (LLC-PK1) cells. Although cisplatin is effective against several cancers, its use is limited due to severe nephrotoxicity. Eupatilin is a flavonoid compound isolated from the Artemisia plant and possesses antioxidant as well as potent anticancer properties. In the LLC-PK1 cellular model, the decline in cell viability induced by oxidative stress, such as that induced by cisplatin, was significantly and dose-dependently inhibited by the A. asiatica extract and eupatilin. The increased protein expressions of phosphorylated JNK and p38 by cisplatin in cells were markedly reduced after A. asiatica extract or eupatilin cotreatment. The elevated expression of cleaved caspase-3 was significantly reduced by A. asiatica extract and eupatilin, and the elevated percentage of apoptotic cells after cisplatin treatment in LLC-PK1 cells was markedly decreased by cotreatment with A. asiatica extract or eupatilin. Taken together, these results suggest that A. asiatica extract and eupatilin could cure or prevent cisplatin-induced renal toxicity without any adverse effect; thus, it can be used in combination with cisplatin to prevent nephrotoxicity. English HINDAWI LTD GENTAMICIN-INDUCED NEPHROTOXICITY CELL-DEATH APOPTOSIS ACTIVATION EXPRESSION DA-9601 COMPONENTS INDUCTION FAILURE GINSENG Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage Article 10.1155/2015/483980 1 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2015 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015 scie scopus 000363588300001 2-s2.0-84945907559 Integrative & Complementary Medicine Integrative & Complementary Medicine Article GENTAMICIN-INDUCED NEPHROTOXICITY CELL-DEATH APOPTOSIS ACTIVATION EXPRESSION DA-9601 COMPONENTS INDUCTION FAILURE GINSENG