Kim, Myungsuk Park, Young Gyun Lee, Hee-Ju Lim, Sue Ji Ahn, Hong Ryul Jung, Sang Hoon Nho, Chu Won 2024-01-20T06:03:01Z 2024-01-20T06:03:01Z 2021-09-04 2015-10 1756-4646 https://pubs.kist.re.kr/handle/201004/124975 Obesity and nonalcoholic fatty liver disease (NAFLD) are characterized by excessive accumulation of triacylglycerol and dysregulation of lipid metabolism. This study investigated the effects of Youngia denticulata extract (YDE) on obesity, hepatic steatosis, inflammation, and antioxidant defences in high-fat diet (HFD)-induced obesity in mice and the molecular mechanisms activated by YDE in HepG2 hepatoma cells. YDE reduced lipid accumulation in HepG2 cells by regulating the expression of lipid metabolism-related enzymes and activating AMP-activated protein kinase (AMPK) signalling. Oral administration of YDE (25 or 100 mg/kg day) to HFD-fed mice lowered the total body weight, adipose and liver tissue weight, insulin resistance, fat deposition, and serum lipids and leptin levels, and augmented the antioxidant enzymes in serum. YDE also altered the expression of lipid metabolism-related enzymes and activated AMPK signalling in liver and white adipose tissue. These results indicate that YDE may be a potent anti-obesity agent. (C) 2015 Elsevier Ltd. All rights reserved. English ELSEVIER SCIENCE BV FATTY LIVER-DISEASE INSULIN-RESISTANCE OXIDATIVE STRESS HEPATIC LIPOGENESIS CHLOROGENIC ACID CAFFEIC ACID MECHANISMS STEATOSIS Youngia denticulata attenuates diet-induced obesity-related metabolic dysfunctions by activating AMP-activated protein kinase and regulating lipid metabolism Article 10.1016/j.jff.2015.09.002 1 JOURNAL OF FUNCTIONAL FOODS, v.18, pp.714 - 726 JOURNAL OF FUNCTIONAL FOODS 18 714 726 scie scopus 000367757400067 2-s2.0-84942524626 Food Science & Technology Nutrition & Dietetics Food Science & Technology Nutrition & Dietetics Article FATTY LIVER-DISEASE INSULIN-RESISTANCE OXIDATIVE STRESS HEPATIC LIPOGENESIS CHLOROGENIC ACID CAFFEIC ACID MECHANISMS STEATOSIS Youngia denticulata Obesity Fatty liver Lipid accumulation AMP-activated protein kinase