Kim, Kyung-A Kang, Suk Woo Ahn, Hong Ryul Song, Youngwoo Yang, Sung Jae Jung, Sang Hoon 2024-01-20T06:04:00Z 2024-01-20T06:04:00Z 2021-09-05 2015-09-09 0021-8561 https://pubs.kist.re.kr/handle/201004/125026 The purpose of the study was to investigate the protective effects of the ethanol extract of Diospyros kaki (EEDK) persimmon leaves to study N-methyl-N-nitrosourea (MNU)-induced retinal degeneration in mice. EEDK was orally administered after MNU injection. Retinal layer thicknesses were significantly increased in the EEDK-treated group compared with the MNU-treated group. The outer nuclear layer was preserved in the retinas of EEDK-treated mice. Moreover, EEDK treatment reduced the MNU-dependent up-regulation of glial fibrillary acidic protein (GFAP) and nestin expression in Muller and astrocyte cells. EEDK treatment also inhibited MNU-dependent down-regulation of rhodopsin expression. Quercetin exposure significantly attenuated the negative effects of H2O2 in R28 cells, suggesting that quercetin can act in an antioxidative capacity. Thus, EEDK may be considered as an agent for treating or preventing degenerative retinal diseases, such as retinitis pigmentosa and age-related macular degeneration. English AMER CHEMICAL SOC CONE CELL-DEATH PHOTORECEPTOR DEGENERATION SMALL-INTESTINE MULLER CELLS NESTIN EXPRESSION ANTIOXIDANTS GLYCOSIDES QUERCETIN CATARACT Leaves of Persimmon (Diospyros kaki Thunb.) Ameliorate N-Methyl-N-nitrosourea (MNU)-Induced Retinal Degeneration in Mice Article 10.1021/acs.jafc.5b02578 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.63, no.35, pp.7750 - 7759 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63 35 7750 7759 scie scopus 000361252100021 2-s2.0-84941065713 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article CONE CELL-DEATH PHOTORECEPTOR DEGENERATION SMALL-INTESTINE MULLER CELLS NESTIN EXPRESSION ANTIOXIDANTS GLYCOSIDES QUERCETIN CATARACT Diospyros kaki N-methyl-N-nitrosourea persimmon photoreceptor retinal degeneration