Li, Lin Zhang, Cheng-Wu Ge, Jingyan Qian, Linghui Chai, Bing-Han Zhu, Qing Lee, Jun-Seok Lim, Kah-Leong Yao, Shao Q. 2024-01-20T06:04:05Z 2024-01-20T06:04:05Z 2021-09-05 2015-09-07 1433-7851 https://pubs.kist.re.kr/handle/201004/125030 The design of the first dual-purpose activity-based probe of monoamine oxidaseB (MAO-B) is reported. This probe is highly selective towards MAO-B, even at high MAO-A expression levels, and could sensitively report endogenous MAO-B activities by both insitu proteome profiling and live-cell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems. English John Wiley & Sons Ltd. MAO-A TARGET IDENTIFICATION FLUOROGENIC PROBES B INHIBITORS APOPTOSIS EXPRESSION A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine OxidaseB Activities in Models of Parkinson's Disease Article 10.1002/anie.201504441 1 Angewandte Chemie International Edition, v.54, no.37, pp.10821 - 10825 Angewandte Chemie International Edition 54 37 10821 10825 scie scopus 000360628500019 2-s2.0-84940720973 Chemistry, Multidisciplinary Chemistry Article MAO-A TARGET IDENTIFICATION FLUOROGENIC PROBES B INHIBITORS APOPTOSIS EXPRESSION activity-based probes imaging monoamine oxidases Parkinson&apos s disease proteomics