Ryu, In Sun Roh, Jong-Lyel Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon 2024-01-20T06:30:25Z 2024-01-20T06:30:25Z 2021-09-05 2015-09 1043-3074 https://pubs.kist.re.kr/handle/201004/125079 BackgroundWe examined the prognostic value of lymph node density in predicting cancer-specific mortality (CSM) for patients with lymph nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy. MethodsThe records of 156 patients with laryngeal SCC who initially underwent curative resection of the primary tumor combined with neck dissection were reviewed. ResultsThe 5-year cumulative incidence of CSM was 20.4%. N classification and extralaryngeal spread (ELS) were independent variables for CSM in all patients. Univariate analyses in 71 pN+ patients showed that ELS, number of positive lymph nodes >4, and lymph node density >0.044 were significantly associated with increased CSM, whereas pN classification was not (p=.218). On multivariate analysis, lymph node density 0.044 remained an independent predictor of CSM (p=.001). ConclusionAmong the pN+ patients with laryngeal SCC, no pN classification but lymph node density was noted to have an independent impact on CSM. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 1319-1325, 2015 English WILEY LOCALLY ADVANCED HEAD PROGNOSTIC-SIGNIFICANCE EXTRACAPSULAR SPREAD SURVIVAL CHEMOTHERAPY SOCIETY RATIO Lymph node density as an independent predictor of cancer-specific mortality in patients with lymph node-positive laryngeal squamous cell carcinoma after laryngectomy Article 10.1002/hed.23750 1 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.37, no.9, pp.1319 - 1325 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 37 9 1319 1325 scie scopus 000359605700017 2-s2.0-84938981776 Otorhinolaryngology Surgery Otorhinolaryngology Surgery Article LOCALLY ADVANCED HEAD PROGNOSTIC-SIGNIFICANCE EXTRACAPSULAR SPREAD SURVIVAL CHEMOTHERAPY SOCIETY RATIO lymph node density laryngeal cancer laryngectomy squamous cell carcinoma mortality