Kim, Joonki Park, Yurim Chun, Yoon Sun Cha, Jin Wook Kwon, Hak Cheol Oh, Myung Sook Chung, Sungkwon Yang, Hyun Ok 2024-01-20T06:31:20Z 2024-01-20T06:31:20Z 2021-09-05 2015-08 0021-8561 https://pubs.kist.re.kr/handle/201004/125123 We found that an extract of Lycoris chejuensis and its three isolated active components, narciclasine, 7-deoxynarciclasine, and 7-deoxy-trans-dihydronarciclasine, each significantly reduced the formation of amyloid-beta peptides in HeLa cells transfected with an amyloid precursor protein carrying the Swedish mutation up to 45 +/- 3.6%. The extract down-regulated amyloid precursor protein, especially the mature form by up to 88%, and reduced the ability of secretases to generate toxic amyloid-beta. Double-transgenic mice treated with the extract for 4 months also showed significantly reduced levels of amyloid-beta and plaques while exhibiting improved memory functions in the Morris water maze and novel object recognition tests. In conclusion, the extract and isolated active components of L. chejuensis decreased the production of amyloid-beta by attenuating amyloid precursor protein levels. Furthermore, the extract improved the disrupted memory functions in animals while inhibiting amyloid plaque formation. Thus, this extract, as well as its active components, could prove beneficial in the treatment of Alzheimer's disease. English American Chemical Society Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer's Disease Article 10.1021/acs.jafc.5b00889 1 Journal of Agricultural and Food Chemistry, v.63, no.31, pp.6979 - 6988 Journal of Agricultural and Food Chemistry 63 31 6979 6988 N scie scopus 000359613400016 2-s2.0-84938723461 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article AMYLOID PRECURSOR PROTEIN ALPHA-SECRETASE CLEAVAGE NECROSIS-FACTOR-ALPHA BETA-SECRETASE CELL BIOLOGY ENZYME MEMORY NEURONS CHINESE DRUG Lycoris chejuensis Alzheimer&apos s disease Amyloid-beta Amyloid-beta precursor protein Narciclasine