Lee, Young Hun Kim, Hyoung Ja Yoo, Ho Jung, Seo Yun Kwon, Bong Jin Kim, Nam-Jung Jin, Changbae Lee, Yong Sup 2024-01-20T06:31:40Z 2024-01-20T06:31:40Z 2021-09-05 2015-08-01 0968-0896 https://pubs.kist.re.kr/handle/201004/125141 Reactive oxygen species have been implicated in several diseases, particularly in ischemia-reperfusion injury. Quercetin 3-O-methyl ether has been reported to show potent antioxidant and neuroprotective activity against neuronal damage induced by reactive oxygen species. Several aminoethyl-substituted derivatives of quercetin 3-O-methyl ether have been synthesized to increase water solubility while retaining antioxidant and neuroprotective activity. Among such derivatives, compound 3a shows potent and well-balanced antioxidant activity in three types of cell-free assay systems and has in vivo neuroprotective effects on transient focal ischemic injury induced by the occlusion of the middle cerebral artery in rats. (C) 2015 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD MOLECULAR-MECHANISMS PEROXIDATION FLAVONOIDS ISCHEMIA DISEASE Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects Article 10.1016/j.bmc.2015.05.023 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.23, no.15, pp.4970 - 4979 BIOORGANIC & MEDICINAL CHEMISTRY 23 15 4970 4979 scie scopus 000358440000088 2-s2.0-84937517867 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article MOLECULAR-MECHANISMS PEROXIDATION FLAVONOIDS ISCHEMIA DISEASE Quercetin 3-O-methyl ether Aminoethyl Antioxidant Neuroprotection MCAO model