Lee, Woojung Ham, Jungyeob Kwon, Hak Cheol Yoon, Goo Bae, Gyu-Un Kim, Yong Kee Kim, Su-Nam 2024-01-20T06:32:27Z 2024-01-20T06:32:27Z 2021-09-05 2015-08 1107-3756 https://pubs.kist.re.kr/handle/201004/125183 In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low-density lipoprotein-cholesterol levels are decreased in AF- or APH-treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin-signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism. English SPANDIDOS PUBL LTD PROTEIN-TYROSINE PHOSPHATASES PPAR-ALPHA/GAMMA AGONIST INSULIN SENSITIVITY EXPRESSION OBESITY WEIGHT ROSIGLITAZONE MURAGLITAZAR PATHOGENESIS RESISTANCE Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet Article 10.3892/ijmm.2015.2227 1 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.36, no.2, pp.527 - 533 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 36 2 527 533 scie scopus 000358677000024 2-s2.0-84934268197 Medicine, Research & Experimental Research & Experimental Medicine Article PROTEIN-TYROSINE PHOSPHATASES PPAR-ALPHA/GAMMA AGONIST INSULIN SENSITIVITY EXPRESSION OBESITY WEIGHT ROSIGLITAZONE MURAGLITAZAR PATHOGENESIS RESISTANCE Amorpha fruticosa amorphastilbol peroxisome proliferator-activated receptor alpha/gamma agonist protein tyrosine phosphatase 1B insulin resistance