Eom, Dae-Woon Lee, Ji Hwan Kim, Young-Joo Hwang, Gwi Seo Kim, Su-Nam Kwak, Jin Ho Cheon, Gab Jin Kim, Ki Hyun Jang, Hyuk-Jai Ham, Jungyeob Kang, Ki Sung Yamabe, Noriko 2024-01-20T06:32:33Z 2024-01-20T06:32:33Z 2021-09-05 2015-08 1976-6696 https://pubs.kist.re.kr/handle/201004/125189 Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers. EGCG showed weaker inhibitory effect on PC3 cell proliferation than two other prostate cancer cell lines, LNCaP and DU145. Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells. The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound. Moreover, treatments of EGCG and curcumin arrested both S and G2/M phases of PC3 cells. These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest. English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY GREEN TEA POLYPHENOLS IN-VITRO PANCREATIC-CANCER GROWTH-INHIBITION APOPTOSIS CHEMOPREVENTION INDUCTION CATECHINS VIVO COMBINATION Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells Article 10.5483/BMBRep.2015.48.8.216 1 BMB REPORTS, v.48, no.8, pp.461 - 466 BMB REPORTS 48 8 461 466 scie scopus kci ART002020728 000360312900007 2-s2.0-84944754102 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article GREEN TEA POLYPHENOLS IN-VITRO PANCREATIC-CANCER GROWTH-INHIBITION APOPTOSIS CHEMOPREVENTION INDUCTION CATECHINS VIVO COMBINATION Curcumin Epigallocatechin gallate Growth arrest Prostate cancer p21