Jo, Seongil Woo, Hae Dong Kwon, Ho-Jang Oh, Se-Young Park, Jung-Duck Hong, Young-Seoub Pyo, Heesoo Park, Kyung Su Ha, Mina Kim, Ho Sohn, Seok-Joon Kim, Yu-Mi Lim, Ji-Ae Lee, Sang-Ah Eom, Sang-Yong Kim, Byoung-Gwon Lee, Kyoung-Mu Lee, Jong-Hyeon Hwang, Myung Sil Kim, Jeongseon 2024-01-20T06:32:38Z 2024-01-20T06:32:38Z 2021-09-04 2015-08 1661-7827 https://pubs.kist.re.kr/handle/201004/125194 Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 +/- 8.6 days. The population mean of the methylmercury half-life was 81.6 +/- 8.4 days for men and 78.9 +/- 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 +/- 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. English MDPI AG POLYUNSATURATED FATTY-ACIDS METHYL MERCURY FISH CONSUMPTION BLOOD EXPOSURE HUMANS HAIR VARIABILITY INGESTION Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model Article 10.3390/ijerph120809054 1 INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.12, no.8, pp.9054 - 9067 INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 12 8 9054 9067 scie scopus 000360587800028 2-s2.0-84938535661 Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology Public, Environmental & Occupational Health Article POLYUNSATURATED FATTY-ACIDS METHYL MERCURY FISH CONSUMPTION BLOOD EXPOSURE HUMANS HAIR VARIABILITY INGESTION biological half-life dietary exposure methylmercury one-compartment toxicokinetic model population model