Na, Yu-Ran Woo, Dustin J. Choo, Hyunah Chung, Hak Suk Yang, Eun Gyeong 2024-01-20T06:34:17Z 2024-01-20T06:34:17Z 2021-09-05 2015-07 1359-7345 https://pubs.kist.re.kr/handle/201004/125282 We report herein that Zn(II) selectively inhibits the hypoxia- inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site. English ROYAL SOC CHEMISTRY Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II) Article 10.1039/c5cc02143j 1 CHEMICAL COMMUNICATIONS, v.51, no.53, pp.10730 - 10733 CHEMICAL COMMUNICATIONS 51 53 10730 10733 N scie scopus 000356453200034 2-s2.0-84934931664 Chemistry, Multidisciplinary Chemistry Article ERYTHROPOIETIN GENE HIF-ALPHA FACTOR-I BINDING DESFERRIOXAMINE COPPER