Huh, Yeowool Cho, Jeiwon 2024-01-20T07:00:36Z 2024-01-20T07:00:36Z 2021-09-05 2015-06-12 1932-6203 https://pubs.kist.re.kr/handle/201004/125330 The sensory thalamus has been reported to play a key role in central pain sensory modulation and processing, but its response to repeated nociception at thalamic level is not well known. Current study investigated thalamic response to repeated nociception by recording and comparing the activity of the same thalamic neuron during the 1st and 2nd formalin injection induced nociception, with a week interval between injections, in awake and behaving mice. Behaviorally, the 2nd injection induced greater nociceptive responses than the 1st. Thalamic activity mirrored these behavioral changes with greater firing rate during the 2nd injection. Analysis of tonic and burst firing, characteristic firing pattern of thalamic neurons, revealed that tonic firing activity was potentiated while burst firing activity was not significantly changed by the 2nd injection relative to the 1st. Likewise, burst firing property changes, which has been consistently associated with different phases of nociception, were not induced by the 2nd injection. Overall, data suggest that repeated nociception potentiated responsiveness of thalamic neurons and confirmed that tonic firing transmits nociceptive signals. English PUBLIC LIBRARY SCIENCE SPINAL-CORD-INJURY ECCENTRIC EXERCISE THALAMOCORTICAL DYSRHYTHMIA REPEATED BOUTS MUSCLE DAMAGE FORMALIN TEST CENTRAL PAIN STIMULATION RAT INHIBITION Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice Article 10.1371/journal.pone.0129395 1 PLOS ONE, v.10, no.6 PLOS ONE 10 6 scie scopus 000356327000072 2-s2.0-84935449292 Multidisciplinary Sciences Science & Technology - Other Topics Article SPINAL-CORD-INJURY ECCENTRIC EXERCISE THALAMOCORTICAL DYSRHYTHMIA REPEATED BOUTS MUSCLE DAMAGE FORMALIN TEST CENTRAL PAIN STIMULATION RAT INHIBITION