Dash, Uttam Sengupta, Sandip Sim, Taebo 2024-01-20T07:01:05Z 2024-01-20T07:01:05Z 2022-01-10 2015-06 1434-193X https://pubs.kist.re.kr/handle/201004/125355 A highly stereoselective, concise (14 steps longest linear sequence and 20 steps overall), and efficient (15% overall yield) synthesis of militarinone D has been accomplished. The key reactions utilized in the sequence are enzymatic desymmetrization, cis/trans isomerization, Horner-Wadsworth-Emmons olefination, and addition of an organolithium species to a highly conjugated chiral aldehyde. The simplicity of the strategy may enable its utilization in the large-scale production of this target. Moreover, the strategy utilized to design the route should be applicable to the preparation of analogs that bear a variety of substituted pyridinone core structures. English WILEY-V C H VERLAG GMBH ASYMMETRIC-SYNTHESIS PYRIDONE ALKALOIDS METABOLITES TENELLIN A Concise and Efficient Total Synthesis of Militarinone D Article 10.1002/ejoc.201500380 1 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v.2015, no.18, pp.3963 - 3970 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2015 18 3963 3970 scie scopus 000356826300011 2-s2.0-85027951530 Chemistry, Organic Chemistry Article ASYMMETRIC-SYNTHESIS PYRIDONE ALKALOIDS METABOLITES TENELLIN Synthetic methods Asymmetric synthesis Natural products Nitrogen heterocycles