Jo, Hyoung Jung, Sang Hoon Bin Yim, Hye Lee, Sung Jin Kang, Kui Dong 2024-01-20T07:02:22Z 2024-01-20T07:02:22Z 2021-09-04 2015-05-31 1976-6696 https://pubs.kist.re.kr/handle/201004/125421 Baicalin is a flavonoid derived from the dried root of Scutellaria baicalensis. In this study, oxygen-induced retinopathy was used to characterize the anti-angiogenic properties of baicalin in mice. Pups were exposed to a hyperbaric oxygen environment to induce retinal angiogenesis and were subjected to intraperitoneal injection of baicalin. Avascular area, neovascular tufts, and neovascular lumens were quantified from digital images. Compared to the vehicle, baicalin clearly reduced the central avascular zone and the number of neovascular tufts and lumens. High-dose baicalin (10 mg/kg) significantly reduced the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, angiotensin II, and vascular endothelial growth factor (VEGF). These results show that baicalin is a powerful anti-angiogenic compound that attenuates new vessel formation in the retina after systemic administration, and is a candidate substance for therapeutic inhibition of retinal angiogenesis. English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY OXYGEN-INDUCED RETINOPATHY PHOTOCOAGULATION ANGIOGENESIS CRYOTHERAPY The effect of baicalin in a mouse model of retinopathy of prematurity Article 10.5483/BMBRep.2015.48.5.131 1 BMB REPORTS, v.48, no.5, pp.271 - 276 BMB REPORTS 48 5 271 276 scie scopus kci 000355186400007 2-s2.0-84930886706 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article OXYGEN-INDUCED RETINOPATHY PHOTOCOAGULATION ANGIOGENESIS CRYOTHERAPY Angiogenesis Angiotensin II Baicalin Oxygen-induced retinopathy VEGF