Lee, Dahae Kim, Ki Hyun Moon, Sung Won Lee, Heesu Kang, Ki Sung Lee, Jae Wook 2024-01-20T07:03:11Z 2024-01-20T07:03:11Z 2021-09-05 2015-05-01 0960-894X https://pubs.kist.re.kr/handle/201004/125462 Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells. (C) 2015 Published by Elsevier Ltd. English Pergamon Press Ltd. INDUCED APOPTOSIS ANTICANCER INJURY INVOLVEMENT DERIVATIVES PATHWAYS GINSENG DAMAGE ALPHA Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells Article 10.1016/j.bmcl.2015.03.026 1 Bioorganic & Medicinal Chemistry Letters, v.25, no.9, pp.1929 - 1932 Bioorganic & Medicinal Chemistry Letters 25 9 1929 1932 scie scopus 000353205000022 2-s2.0-84933497715 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article INDUCED APOPTOSIS ANTICANCER INJURY INVOLVEMENT DERIVATIVES PATHWAYS GINSENG DAMAGE ALPHA Chalcone Cisplatin-induced nephrotoxicity Renoprotection MAPKs-p53-caspase-3