Lee, Do Yup Kim, Eosu Choi, Man Ho 2024-01-20T07:04:31Z 2024-01-20T07:04:31Z 2021-09-05 2015-04-30 1976-6696 https://pubs.kist.re.kr/handle/201004/125530 Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases. Acute stress may induce an individual's adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through "allostatic load". Thus, monitoring the quantified levels of long-term stress mediators would provide a timely opportunity for prevention or earlier intervention of stress-related chronic illnesses. Although either acute or chronic stress could be quantified through measurement of changes in physiological parameters such as heart rate, blood pressure, and levels of various metabolic hormones, it is still elusive to interpret whether the changes in circulating levels of stress mediators such as cortisol can reflect the acute, chronic, or diurnal variations. Both serum and salivary cortisol levels reveal acute changes at a single point in time, but the overall long-term systemic cortisol exposure is difficult to evaluate due to circadian variations and its protein-binding capacity. Scalp hair has a fairy predictable growth rate of approximately 1 cm/month, and the most 1 cm segment approximates the last month's cortisol production as the mean value. The analysis of cortisol in hair is a highly promising technique for the retrospective assessment of chronic stress. English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY URINARY FREE CORTISOL HAIR CORTISOL SCALP HAIR METABOLOMICS CORTICOSTEROIDS DIAGNOSIS BIOMARKER DISORDER PATTERN OBESITY Technical and clinical aspects of cortisol as a biochemical marker of chronic stress Article 10.5483/BMBRep.2015.48.4.275 1 BMB REPORTS, v.48, no.4, pp.209 - 216 BMB REPORTS 48 4 209 216 scie scopus kci ART001985160 000355185300004 2-s2.0-84929297665 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Review URINARY FREE CORTISOL HAIR CORTISOL SCALP HAIR METABOLOMICS CORTICOSTEROIDS DIAGNOSIS BIOMARKER DISORDER PATTERN OBESITY Allostasis Cortisol Hair Mass spectrometry Metabolomics Stress