Jang, Hyuk Jai Jeong, Eui Kyun Kim, Seong Su Lee, Ji Hwan Oh, Mi Young Kang, Ki Sung Kwan, Hak Cheol Song, Kyung Il Eom, Dae Woon Han, Duck Jong 2024-01-20T07:30:35Z 2024-01-20T07:30:35Z 2022-01-25 2015-04 1304-0855 https://pubs.kist.re.kr/handle/201004/125574 Objectives: An extract of Artemisia asiatica was reported to possess antioxidative and cytoprotective actions in various experiments. lschemia-reperfusion injury remains a major problem in kidney transplant, and the inflammatory response to ischemia-reperfusion injury exacerbates the resultant renal injury. In the present study, we investigated whether an extract of Artemisia asiatica exhibits renoprotective effects against ischemia-reperfusion-induced acute kidney injury in mice. Materials and Methods: Renal ischemia-reperfusion injury was induced in male C57BL/6 mice by bilateral renal pedicle occlusion for 30 minutes followed by reperfusion for 48 hours. An extract of Artemisia asiatica (100 mg/kg oral) was administered 4 days before ischemia-reperfusion injury. Sham operation and phosphate-buffered saline were used as controls. Blood and renal tissues were evaluated at 48 hours after ischemia-reperfusion injury. Results: Treatment with an extract of Artemisia asiatica significantly decreased blood urea nitrogen, serum creatinine levels, and kidney tubular injury (P <= .05). Western blot showed that an extract of Artemisia asiatica significantly increased the level of heme oxygenase-1 and B-cell lymphoma 2 at 48 hours after ischemia-reperfusion injury and attenuated the level of inducible nitric oxide synthase. Conclusions: An extract of Artemisia asiatica improves acute renal ischemia-reperfusion injury by reducing inflammation and apoptosis. These findings suggest that an extract of Artemisia asiatica is a potential therapeutic agent against acute ischemia-induced renal damage. English BASKENT UNIV APOPTOSIS FAILURE INFLAMMATION KIDNEY RATS INHIBITION INDUCTION NECROSIS DA-9601 Protective Effect of Artemisia Asiatica Extract Against Renal Ischemia-Reperfusion Injury in Mice Article 10.6002/ect.mesot2014.P227 1 EXPERIMENTAL AND CLINICAL TRANSPLANTATION, v.13, pp.377 - 382 EXPERIMENTAL AND CLINICAL TRANSPLANTATION 13 377 382 scie scopus 000355058400078 2-s2.0-84939810588 Transplantation Transplantation Article; Proceedings Paper APOPTOSIS FAILURE INFLAMMATION KIDNEY RATS INHIBITION INDUCTION NECROSIS DA-9601 Heme oxygenase-1 Inducible nitric oxide synthase Kidney transplant Renal failure