Abdelazem, Ahmed Z. Lee, So Ha 2024-01-20T07:30:51Z 2024-01-20T07:30:51Z 2021-09-05 2015-04 1475-6366 https://pubs.kist.re.kr/handle/201004/125588 As a part of trials to target ROS1 kinase with potential inhibitors, a novel series of pyrimidin-4-ylethanol and ethanone derivatives (4a-f, 5a-f, 6a-f and 7a-f) have been designed based on previously discovered lead compounds KIST301072 and KIST301080, and synthesized on 4-5 steps according to compounds. The structures of the newly synthesized compounds have been confirmed on H-1-NMR, C-13-NMR and IR. Most of the tested compounds showed ROS1 kinase inhibitory activity in micromolar range. English INFORMA HEALTHCARE PROTEIN-KINASES CANCER TARGETS Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors Article 10.3109/14756366.2014.920838 1 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.30, no.2, pp.290 - 298 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 30 2 290 298 scie scopus 000352274500019 2-s2.0-84926485874 Biochemistry & Molecular Biology Chemistry, Medicinal Biochemistry & Molecular Biology Pharmacology & Pharmacy Article PROTEIN-KINASES CANCER TARGETS Drug non-small cell lung cancer receptor tyrosine kinase ROS1