Choi, Pilju Park, Jun Yeon Kim, Taejung Park, Soon-Hye Kim, Ho-Kyong Kang, Ki Sung Ham, Jungyeoh 2024-01-20T07:31:33Z 2024-01-20T07:31:33Z 2021-09-04 2015-04 1756-4646 https://pubs.kist.re.kr/handle/201004/125627 In this study, we demonstrated the efficient structural conversion of ginsenosides, which enhances the anticancer activity of ginseng by microwave irradiation. The microwave-irradiated product of ginseng (MG) had a higher content of ginsenosides, Rg3+Rg5+Rk1, particularly Rg5 and Rk1, and, thus, has an increased medicinal effect. To confirm the anticancer effect of MG, it was tested in 5 human cancer cell lines (cervical cancer HeLa, gastric cancer AGS, colon cancer HCT-116, lung cancer A549, and liver cancer HepG2 cells). Anti-proliferation results for 5 human cancer cell lines treated with ginseng extracts indicate that HeLa cells treated with MG showed the highest activity with an IC50 value of 130.1 mu g/mL. MG also suppressed the growth of human cervical cancer cell xenografts in athymic nude mice as an in vivo model. This growth suppression by MG is associated with the induction of cell death and autophagy. Moreover, there were no toxic sign or decrease in renal and hepatic function in mice administered with MG. Therefore, heat processing by microwave irradiation is a useful method to enhance the anticancer effect of ginseng as it increases the content of ginsenosides, Rg3, Rg5, and Rk1. (C) 2015 Elsevier Ltd. All rights reserved. English ELSEVIER SCIENCE BV HEPATOCELLULAR-CARCINOMA CELLS SCAVENGING ACTIVITY CHANGES MAILLARD REACTION AMERICAN GINSENG CERVICAL-CANCER APOPTOSIS ROOT RE ANTIOXIDANT INHIBITION Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1 Article 10.1016/j.jff.2015.02.038 1 JOURNAL OF FUNCTIONAL FOODS, v.14, pp.613 - 622 JOURNAL OF FUNCTIONAL FOODS 14 613 622 scie scopus 000364500000062 2-s2.0-84926308743 Food Science & Technology Nutrition & Dietetics Food Science & Technology Nutrition & Dietetics Article HEPATOCELLULAR-CARCINOMA CELLS SCAVENGING ACTIVITY CHANGES MAILLARD REACTION AMERICAN GINSENG CERVICAL-CANCER APOPTOSIS ROOT RE ANTIOXIDANT INHIBITION Ginseng Microwave Ginsenoside Cervical cancer Cell death