Lee, Jun-Seok Lee, Jae Wook Kang, Namyoung Ha, Hyung-Ho Chang, Young-Tae 2024-01-20T07:31:37Z 2024-01-20T07:31:37Z 2021-09-04 2015-04 1527-8999 https://pubs.kist.re.kr/handle/201004/125630 Synthetic molecules that modulate and probe biological events are critical tools in chemical biology. Utilizing combinatorial and diversity-oriented synthetic strategies, access to large numbers of small molecules is becoming more and more feasible, and research groups in this field can take advantage of the power of chemical diversity. Since the majority of early studies were focused on the discovery of compounds that perturb protein functions, diversity-based approaches are often considered as therapeutic lead discovery tactics. However, the diversity-oriented approach can also be applied to advance distinct aims, such as target protein identification, or the development of imaging probes and sensors. This review provides a personal perspective of the chemical-diversity-based approach and how this principle can be adapted to various chemical biology studies. English WILEY-V C H VERLAG GMBH COLORIMETRIC SENSOR ARRAY FLUORESCENCE LIBRARY APPROACH HUMAN SERUM-ALBUMIN DYNAMIC COMBINATORIAL LIBRARIES IMAGING PROBE DEVELOPMENT PLURIPOTENT STEM-CELLS SOLID-PHASE SYNTHESIS METAL-DYE COMPLEXES DATE RAPE DRUG TRIAZINE LIBRARY Diversity-Oriented Approach for Chemical Biology Article 10.1002/tcr.201402087 1 CHEMICAL RECORD, v.15, no.2, pp.495 - 510 CHEMICAL RECORD 15 2 495 510 scie scopus 000353919100005 2-s2.0-84927754240 Chemistry, Multidisciplinary Chemistry Article COLORIMETRIC SENSOR ARRAY FLUORESCENCE LIBRARY APPROACH HUMAN SERUM-ALBUMIN DYNAMIC COMBINATORIAL LIBRARIES IMAGING PROBE DEVELOPMENT PLURIPOTENT STEM-CELLS SOLID-PHASE SYNTHESIS METAL-DYE COMPLEXES DATE RAPE DRUG TRIAZINE LIBRARY fluorescent probes high-throughput screening molecular diversity sensors target identification