Kim, Tae Thankachan, Stephen McKenna, James T. McNally, James M. Yang, Chun Choi, Jee Hyun Chen, Lichao Kocsis, Bernat Deisseroth, Karl Strecker, Robert E. Basheer, Radhika Brown, Ritchie E. McCarley, Robert W. 2024-01-20T07:32:10Z 2024-01-20T07:32:10Z 2021-09-05 2015-03-17 0027-8424 https://pubs.kist.re.kr/handle/201004/125659 Cortical gamma band oscillations (GBO, 30-80 Hz, typically similar to 40 Hz) are involved in higher cognitive functions such as feature binding, attention, and working memory. GBO abnormalities are a feature of several neuropsychiatric disorders associated with dysfunction of cortical fast-spiking interneurons containing the calcium-binding protein parvalbumin (PV). GBO vary according to the state of arousal, are modulated by attention, and are correlated with conscious awareness. However, the subcortical cell types underlying the state-dependent control of GBO are not well understood. Here we tested the role of one cell type in the wakefulness-promoting basal forebrain (BF) region, cortically projecting GABAergic neurons containing PV, whose virally transduced fibers we found apposed cortical PV interneurons involved in generating GBO. Optogenetic stimulation of BF PV neurons in mice preferentially increased cortical GBO power by entraining a cortical oscillator with a resonant frequency of similar to 40 Hz, as revealed by analysis of both rhythmic and nonrhythmic BF PV stimulation. Selective saporin lesions of BF cholinergic neurons did not alter the enhancement of cortical GBO power induced by BF PV stimulation. Importantly, bilateral optogenetic inhibition of BF PV neurons decreased the power of the 40-Hz auditory steady-state response, a read-out of the ability of the cortex to generate GBO used in clinical studies. Our results are surprising and novel in indicating that this presumptively inhibitory BF PV input controls cortical GBO, likely by synchronizing the activity of cortical PV interneurons. BF PV neurons may represent a previously unidentified therapeutic target to treat disorders involving abnormal GBO, such as schizophrenia. English NATL ACAD SCIENCES NUCLEUS BASALIS CHOLINERGIC NEURONS EVOKED-POTENTIALS WAKE STATES SCHIZOPHRENIA SLEEP ACTIVATION CORTEX RAT INTERNEURONS Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations Article 10.1073/pnas.1413625112 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.112, no.11, pp.3535 - 3540 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 11 3535 3540 scie scopus 000351060000095 2-s2.0-84925274773 Multidisciplinary Sciences Science & Technology - Other Topics Article NUCLEUS BASALIS CHOLINERGIC NEURONS EVOKED-POTENTIALS WAKE STATES SCHIZOPHRENIA SLEEP ACTIVATION CORTEX RAT INTERNEURONS ArchT arousal auditory steady-state response channelrhodopsin2 optogenetics